Endocrine Abstracts

BackgroundAppetite is complex, however to address the obesity epidemic, therapeutic agents would have to significantly influence appetite. Currently the most effective treatment for obesity is bariatric surgery because it reduces hunger and increases satiety. The satiety gut hormones such as peptide YY (PYY) and glucagon like peptide 1 (GLP-1) reduce appetite and food intake. Compared to lean and obese subjects, exaggerated postprandial responses of PYY ...

Energy balance is controlled by the arcuate nucleus through integration of peripheral hormonal signals such as leptin, ghrelin, peptide YY (PYY) and glucagon like peptide 1 (GLP-1). The commonest reason for young women in the developed world to be underweight is restrictive anorexia nervosa (AN). Constitutionally thinness (CT) has been described in young women who satisfies the WHO definition for moderate to severe underweight (BMI 13–16.9 kg/m2). CT women have...